Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | PAM | P19021 | 2/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.36 |
| ▸ | PPARG | P37231 | 6/20 | 0.36 |
| ▸ | PPARD | Q03181 | 6/20 | 0.36 |
| ▸ | PPARA | Q07869 | 6/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TLR2 | O60603 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | FABP4 | P15090 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656500 | 0.90 | FDPS (0.36) | TSHRALDH1A1ESR1 | |
| SCHEMBL8518050 | 0.80 | SMPD1 (0.37) | AKR1B1PAMTDP1KMT2A | |
| SCHEMBL5873986 | 0.79 | AKR1B1 (0.36) | AKR1B1PAMGPR84PPARGPPARD | |
| Bicarbonate SCHEMBL14631950 | 0.79 | NAAA (0.39) | AKR1B1PAMTSHR | |
| SCHEMBL24786822 | 0.76 | FDPS (0.40) | — | |
| SCHEMBL5873985 | 0.76 | FDPS (0.35) | ALDH1A1MEN1KMT2A | |
| SCHEMBL27688964 | 0.74 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL27963221 | 0.74 | FDPS (0.36) | TSHRALDH1A1ESR1 | |
| SCHEMBL9439975 | 0.73 | FDPS (0.38) | ALDH1A1HSD17B10 | |
| SCHEMBL27981471 | 0.73 | FDPS (0.42) | AKR1B1GPR84PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-11140177-A | — | — | None | — | — | JP | disclosed |
| JP-H11140177-A | ULTRAHIGH-MOLECULAR-WEIGHT AROMATIC POLYCARBONATE AND PRODUCTION OF AROMATIC POLYCARBONATE | AGENCY OF IND SCIENCE & TECHNOL | 1999-05-25 | — | — | JP | disclosed |