Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.47 |
| ▸ | KMO | O15229 | 2/20 | 0.44 |
| ▸ | JUN | P05412 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EIF4E | P06730 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8394975 | 0.86 | JUN (0.55) | ALDH1A1JUNNFKB1NFKB2RELA | |
| SCHEMBL8396866 | 0.83 | MAPK1 (0.52) | ALDH1A1JUNNFKB1NFKB2RELA | |
| SCHEMBL4278964 | 0.80 | KMO (0.46) | ALDH1A1L3MBTL1MKNK1MKNK2KMO | |
| SCHEMBL6016346 | 0.79 | KMT2A (0.56) | ALDH1A1L3MBTL1MKNK1MKNK2KMO | |
| SCHEMBL16653633 | 0.78 | RPS6KA5 (0.50) | ALDH1A1LMNAKDM4EHTTSMN1; SMN2 | |
| SCHEMBL3624974 | 0.77 | PTGS1 (0.54) | ALDH1A1L3MBTL1MKNK1MKNK2KMO | |
| SCHEMBL5145882 | 0.76 | KDM4E (0.67) | ALDH1A1L3MBTL1MKNK1MKNK2KMO | |
| SCHEMBL8543261 | 0.75 | JUN (0.54) | ALDH1A1JUNNFKB1NFKB2RELA | |
| Hydrochloric Acid SCHEMBL22719435 | 0.75 | KDM4E (0.65) | ALDH1A1L3MBTL1MKNK1MKNK2KMO | |
| SCHEMBL5792144 | 0.75 | ADORA2A (0.48) | ALDH1A1MKNK1MKNK2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935966-A | COMPOUNDS THAT BLOCK THE ACTIVATION OF TRANSCRIPTION FACTORS THROUGH INHIBITION OF A FAMILY OF SPECIFIC KINASES, DECREASING PROINFLAMMATORY PROTEINS TO TREAT AUTOIMMUNE DISEASES AND AS GENERAL ANTIINFLAMMATORY AGENTS | SIGNAL PHARMACEUTICALS, INC. (US) | 1999-08-10 | — | — | US | disclosed |