Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KMO | O15229 | 2/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.46 |
| ▸ | DHODH | Q02127 | 3/20 | 0.46 |
| ▸ | EIF4E | P06730 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3621439 | 0.83 | MAPK1 (0.55) | PTGS1PTGS2ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL5145882 | 0.80 | KDM4E (0.67) | PTGS2ALDH1A1L3MBTL1KMOMKNK1 | |
| Hydrochloric Acid SCHEMBL22719435 | 0.78 | KDM4E (0.65) | PTGS2ALDH1A1L3MBTL1KMOMKNK1 | |
| SCHEMBL30189226 | 0.78 | DHODH (0.50) | ALDH1A1KMODHODHPIM1SMN1; SMN2 | |
| SCHEMBL3618824 | 0.78 | HCRTR1 (0.60) | KMODHODHCYP2A6LMNAKDM4E | |
| SCHEMBL21290342 | 0.77 | SMN1; SMN2 (0.46) | PTGS1PTGS2ALDH1A1L3MBTL1DHODH | |
| SCHEMBL8518593 | 0.77 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1KMOMKNK1MKNK2 | |
| SCHEMBL5111947 | 0.76 | ALDH1A1 (0.56) | PTGS2ALDH1A1KMODHODHEIF4E | |
| SCHEMBL28852822 | 0.76 | PTGS2 (0.67) | PTGS1PTGS2CYP2A6PIM1 | |
| SCHEMBL28414743 | 0.75 | PTGS1 (0.52) | PTGS1PTGS2ALDH1A1MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410142-B2 | Bipyridine carboxamide orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2013-04-02 | — | — | US | disclosed |
| US-20100063056-A1 | BIPYRIDINE CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. | 2010-03-11 | — | — | US | disclosed |
| EP-2131654-A1 | BIPYRIDINE CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008108991-A1 | BIPYRIDINE CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2008-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063056-A1 | BIPYRIDINE CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, CRHR1 | PTGS1 1553/4885PTGS2 1664/4885ALDH1A1 3191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.