Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5747523 | 0.84 | RAB9A (0.52) | SMN1; SMN2ALDH1A1MAPTGAAHPGD | |
| SCHEMBL14198403 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1MAPTGAAHPGD | |
| SCHEMBL1679708 | 0.84 | CYP3A4 (0.54) | ALDH1A1MAPTGAALMNANPC1 | |
| SCHEMBL5691228 | 0.81 | NPC1 (0.54) | ALDH1A1MAPTGAANPC1FFAR1 | |
| SCHEMBL6840453 | 0.80 | L3MBTL1 (0.55) | SMN1; SMN2ALDH1A1MAPTGAAHPGD | |
| SCHEMBL2413521 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1MAPTGAAHPGD | |
| SCHEMBL1569202 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1MAPTGAAHPGD | |
| SCHEMBL3077683 | 0.78 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1MAPTGAAHPGD | |
| SCHEMBL28155818 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1MAPTGAAHPGD | |
| SCHEMBL379217 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1MAPTGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432771-A1 | ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE | Infinity Pharmaceuticals, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135360-A1 | ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE | INFINITY PHARMACEUTICALS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |