Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.49 |
| ▸ | PPARD | Q03181 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL260421 | 0.86 | LMNA (0.54) | SMN1; SMN2ALDH1A1MAPTGAALMNA | |
| SCHEMBL8989130 | 0.86 | KDM4E (0.54) | MAPTGAALMNARAB9ATP53 | |
| SCHEMBL6840453 | 0.84 | L3MBTL1 (0.55) | SMN1; SMN2ALDH1A1MAPTGAALMNA | |
| SCHEMBL12875924 | 0.83 | LMNA (0.54) | SMN1; SMN2ALDH1A1MAPTGAALMNA | |
| SCHEMBL95917 | 0.83 | RAB9A (0.56) | SMN1; SMN2ALDH1A1MAPTGAALMNA | |
| SCHEMBL4474091 | 0.83 | LMNA (0.48) | SMN1; SMN2ALDH1A1MAPTGAALMNA | |
| SCHEMBL4151388 | 0.82 | LMNA (0.42) | SMN1; SMN2ALDH1A1MAPTLMNANPC1 | |
| SCHEMBL1569202 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1MAPTGAALMNA | |
| SCHEMBL28155818 | 0.82 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1MAPTGAALMNA | |
| SCHEMBL2413521 | 0.82 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1MAPTGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2671575-A1 | Ras inhibitors | Universität Regensburg (DE) | 2013-12-11 | — | — | EP | claimed |
| US-20240166613-A1 | PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2024-05-23 | — | — | US | disclosed |
| US-11897852-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | THE UNIVERSITY OF TOLEDO (US) | 2024-02-13 | — | — | US | disclosed |
| US-20210163431-A1 | PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2021-06-03 | — | — | US | disclosed |
| US-10941125-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | THE UNIVERSITY OF TOLEDO (US) | 2021-03-09 | — | — | US | disclosed |
| US-20190330166-A1 | Proxisome Proliferator Activated Receptor (PPAR) Compounds and Methods of Using the Same | THE UNIVERSITY OF TOLEDO (US) | 2019-10-31 | — | — | US | disclosed |
| US-10351541-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | THE UNIVERSITY OF TOLEDO (US) | 2019-07-16 | — | — | US | disclosed |
| EP-3107908-B1 | PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV HEALTHCARE UK NO 5 LTD (GB) | 2019-03-27 | — | — | EP | disclosed |
| US-20170283385-A1 | Proxisome Proliferator Activated Receptor (PPAR) Compounds and Methods of Using the Same | THE UNIVERSITY OF TOLEDO (US) | 2017-10-05 | — | — | US | disclosed |
| US-9695137-B2 | Analogs of peroxisome proliferator activated receptor (PPAR) agonists, and methods of using the same | THE UNIVERSITY OF TOLEDO (US) | 2017-07-04 | — | — | US | disclosed |
| CN-100475810-C | Novel 2-arylthiazole compounds as pparalpha and ppargamma agonists | HOFFMANN LA ROCHE (CH) | 2009-04-08 | — | — | CN | disclosed |
| US-20070179300-A1 | Process for preparing thiazole derivative and the intermediate compounds for preparing the same | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2007-08-02 | — | — | US | disclosed |
| CN-101007790-A | Oxamic acid derivative, and its preparation method and medicinal uses | BEIJING MOLIKE SCIENCE AND TEC (CN) | 2007-08-01 | — | — | CN | disclosed |
| US-7241901-B2 | Process for preparing thiazole derivative and the intermediate compounds for preparing the same | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2007-07-10 | — | — | US | disclosed |
| CN-1678596-A | Novel 2-arylthiazole compounds as PPAR alpha and PPAR gamma agonists | HOFFMANN LA ROCHE (CH) | 2005-10-05 | — | — | CN | disclosed |
| EP-1537091-A1 | NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMMA AGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2005-06-08 | — | — | EP | disclosed |
| US-6809110-B2 | NONINSULIN DEPENDENT DIABETES; SUCH AS 2-ETHOXY-3-(4-(2-(5-METHYL-2-PHENYL-THIAZOL-4-YL)-ETHOXY)-BENZO(B)THIOPHEN-7-YL)-PROPIONIC ACID | HOFFMANN-LA ROCHE INC. | 2004-10-26 | — | — | US | disclosed |
| US-20040110807-A1 | Thiazole derivatives | HOFFMANN-LA ROCHE INC. | 2004-06-10 | — | — | US | disclosed |
| US-6710063-B1 | Activators of PPAR delta | SMITHKLINE BEECHAM CORPORATION | 2004-03-23 | — | — | US | disclosed |
| WO-2004020420-A1 | NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMA AGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2004-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179300-A1 | Process for preparing thiazole derivative and the intermediate compounds for preparing the same | PPARD, PPARG, PPARA | SMN1; SMN2 4743/4885ALDH1A1 816/4885MAPT 4684/4885 |
| US-20240166613-A1 | PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME | PPARG, PPARA, PPARD | SMN1; SMN2 3781/4885ALDH1A1 1053/4885MAPT 4707/4885 |
| US-20190330166-A1 | Proxisome Proliferator Activated Receptor (PPAR) Compounds and Methods of Using the Same | PPARG, PPARA, PPARD | SMN1; SMN2 3702/4885ALDH1A1 1102/4885MAPT 4708/4885 |
| US-10941125-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | PPARG, PPARA, PPARD | SMN1; SMN2 3702/4885ALDH1A1 1102/4885MAPT 4708/4885 |
| US-10351541-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | PPARG, PPARA, PPARD | SMN1; SMN2 3702/4885ALDH1A1 1102/4885MAPT 4708/4885 |
| US-11897852-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | PPARG, PPARA, PPARD | SMN1; SMN2 3702/4885ALDH1A1 1102/4885MAPT 4708/4885 |
| US-20040110807-A1 | Thiazole derivatives | SLC5A1, GPR119, INSR | SMN1; SMN2 2045/4885ALDH1A1 274/4885MAPT 4327/4885 |
| US-20210163431-A1 | PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME | PPARG, PPARA, PPARD | SMN1; SMN2 3702/4885ALDH1A1 1102/4885MAPT 4708/4885 |
| US-20170283385-A1 | Proxisome Proliferator Activated Receptor (PPAR) Compounds and Methods of Using the Same | PPARG, PPARA, PPARD | SMN1; SMN2 3702/4885ALDH1A1 1102/4885MAPT 4708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.