Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8520137 | 0.89 | NPC1 (0.56) | NPC1TP53MAPTRAB9AKDM4E | |
| SCHEMBL8518781 | 0.86 | NPC1 (0.52) | NPC1TP53MAPTRAB9AKDM4E | |
| SCHEMBL7155399 | 0.83 | NPC1 (0.60) | NPC1TP53MAPTRAB9AKDM4E | |
| SCHEMBL7159278 | 0.82 | NPC1 (0.43) | NPC1TP53MAPTRAB9AKDM4E | |
| SCHEMBL8520141 | 0.76 | NPC1 (0.67) | NPC1TP53MAPTRAB9AKDM4E | |
| SCHEMBL7153692 | 0.76 | NPC1 (0.48) | NPC1TP53MAPTRAB9AKDM4E | |
| SCHEMBL8520036 | 0.75 | KDM4E (0.48) | NPC1TP53MAPTRAB9AKDM4E | |
| SCHEMBL7153769 | 0.75 | HDAC1 (0.39) | NPC1TP53MAPTRAB9AKDM4E | |
| SCHEMBL7550136 | 0.73 | RPS6KA5 (0.46) | NPC1TP53MAPTRAB9AKDM4E | |
| SCHEMBL8563280 | 0.72 | KDM4E (0.39) | NPC1TP53MAPTRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927167-A1 | 2-PHENYL BENZIMIDAZOLE DERIVATIVES AS MCP-1 ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998006703-A1 | 2-PHENYL BENZIMIDAZOLE DERIVATIVES AS MCP-1 ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1998-02-19 | — | — | WO | disclosed |