SCHEMBL8519014

SCHEMBL8519014

Cc1cc(Oc2ccccc2S(=O)(=O)NC(CC=O)C(=O)O)ccc1C(C)C

nearest known ligand 0.75

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 18/20 0.75
ICMT O60725 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8520340 0.84 CASP1 (0.74) CASP1ICMT
SCHEMBL5679090 0.83 CASP1 (1.00) CASP1
SCHEMBL8519018 0.80 CASP1 (0.68) CASP1
SCHEMBL5678964 0.76 CASP1 (0.86) CASP1
SCHEMBL5683116 0.74 CASP1 (0.59) CASP1
SCHEMBL5683297 0.70 CASP1 (0.78) CASP1
SCHEMBL5615819 0.69 CASP1 (0.62) CASP1ICMT
SCHEMBL5615814 0.69 CASP1 (0.62) CASP1ICMT
SCHEMBL7427061 0.69 CASP1 (0.57) CASP1ICMT
SCHEMBL5680749 0.68 CASP1 (0.75) CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0932600-A2 SULFONAMIDE SUBSTITUTED ASPARTIC ACID INTERLEUKIN-1$g(b) CONVERTING ENZYME INHIBITORS WARNER-LAMBERT COMPANY (US) 1999-08-04 EP disclosed
WO-1998016504-A2 SULFONAMIDE SUBSTITUTED ASPARTIC ACID INTERLEUKIN-1β CONVERTING ENZYME INHIBITORS WARNER-LAMBERT COMPANY (US) 1998-04-23 WO disclosed