Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 3/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL851926 | 1.00 | PLA2G2A (0.41) | PLA2G2AARHPGDSLC6A4SLC6A3 | |
| SCHEMBL852815 | 0.84 | KDM4E (0.46) | HPGDKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL852816 | 0.84 | KDM4E (0.46) | HPGDKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL1806066 | 0.82 | KEAP1 (0.46) | ARHPGDKDM4EMEN1KMT2A | |
| SCHEMBL1806068 | 0.82 | KEAP1 (0.46) | ARHPGDKDM4EMEN1KMT2A | |
| SCHEMBL851752 | 0.80 | ALDH1A1 (0.40) | HPGDKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL851753 | 0.80 | ALDH1A1 (0.40) | HPGDKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL852020 | 0.79 | BACE1 (0.51) | HPGDSLC6A4SLC6A3KDM4ESMN1; SMN2 | |
| SCHEMBL852019 | 0.79 | BACE1 (0.51) | HPGDSLC6A4SLC6A3KDM4ESMN1; SMN2 | |
| SCHEMBL24950319 | 0.79 | PLA2G2A (0.46) | PLA2G2AHPGDSLC6A4SLC6A3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432783-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135560-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-11-25 | — | — | WO | disclosed |