Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | SNCA | P37840 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7546708 | 1.00 | ACHE (0.67) | ACHEKDM4EMEN1ALDH1A1TP53 | |
| SCHEMBL7553489 | 0.90 | ACHE (0.55) | ACHEKDM4EMEN1ALDH1A1TP53 | |
| SCHEMBL7548167 | 0.88 | ACHE (0.69) | ACHEKDM4EMEN1ALDH1A1TP53 | |
| SCHEMBL7550061 | 0.88 | ACHE (0.58) | ACHEKDM4EMEN1ALDH1A1TP53 | |
| SCHEMBL7159643 | 0.86 | CCR2 (0.59) | ACHEMEN1KMT2AMAPTHRH4 | |
| SCHEMBL8519744 | 0.84 | ACHE (0.52) | ACHEKDM4EMEN1ALDH1A1TP53 | |
| SCHEMBL7549644 | 0.82 | ACHE (0.64) | ACHEKDM4EALDH1A1TP53HPGD | |
| SCHEMBL8396715 | 0.79 | ALDH1A1 (0.81) | ACHEKDM4EMEN1ALDH1A1TP53 | |
| SCHEMBL7551054 | 0.79 | AURKA (0.71) | ACHEKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL19197277 | 0.79 | ACHE (0.48) | ACHEKDM4EMEN1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927167-A1 | 2-PHENYL BENZIMIDAZOLE DERIVATIVES AS MCP-1 ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998006703-A1 | 2-PHENYL BENZIMIDAZOLE DERIVATIVES AS MCP-1 ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1998-02-19 | — | — | WO | disclosed |