Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7156999 | 0.94 | HRH3 (0.44) | HRH3METAP2METAP1CCR2NPY5R | |
| SCHEMBL7156840 | 0.87 | NPY5R (0.38) | HRH3METAP2METAP1CCR2NPY5R | |
| SCHEMBL7153868 | 0.86 | METAP2 (0.48) | METAP2METAP1NPY5RACHEPTGES | |
| SCHEMBL7546719 | 0.80 | HRH3 (0.48) | HRH3PDE5A | |
| SCHEMBL8556563 | 0.80 | METAP2 (0.43) | METAP2METAP1NPY5RPTGESPDE5A | |
| SCHEMBL7157333 | 0.79 | HRH3 (0.47) | HRH3CCR2TBK1ACHEGRIN2B | |
| SCHEMBL7553497 | 0.78 | HRH3 (0.47) | HRH3METAP2METAP1CCR2NPY5R | |
| SCHEMBL7171505 | 0.77 | CCR2 (0.61) | METAP2METAP1CCR2NPY5RTBK1 | |
| SCHEMBL7159244 | 0.76 | CCR2 (0.51) | HRH3METAP2METAP1CCR2NPY5R | |
| SCHEMBL7549627 | 0.76 | HRH3 (0.52) | HRH3CCR2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927167-A1 | 2-PHENYL BENZIMIDAZOLE DERIVATIVES AS MCP-1 ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998006703-A1 | 2-PHENYL BENZIMIDAZOLE DERIVATIVES AS MCP-1 ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1998-02-19 | — | — | WO | disclosed |