Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 13/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 5/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7156577 | 0.96 | METAP2 (0.46) | METAP2METAP1NPY5RPDE5APTGES | |
| SCHEMBL7153868 | 0.94 | METAP2 (0.48) | METAP2METAP1NPY5RPDE5APTGES | |
| SCHEMBL7156840 | 0.85 | NPY5R (0.38) | METAP2METAP1NPY5RPDE5APDE4A | |
| SCHEMBL7554712 | 0.83 | PTGES (0.34) | PDE5APTGES | |
| SCHEMBL8520010 | 0.80 | HRH3 (0.40) | METAP2METAP1NPY5RPDE5APTGES | |
| SCHEMBL7160110 | 0.80 | PDE5A (0.56) | METAP2METAP1PDE5APDE4APDE4B | |
| SCHEMBL7155316 | 0.78 | TSHR (0.36) | PDE5APTGES | |
| SCHEMBL7158378 | 0.78 | PDE5A (0.55) | METAP2METAP1PDE5APDE4APDE4B | |
| SCHEMBL7553973 | 0.77 | PDE5A (0.53) | METAP2METAP1NPY5RPDE5AAURKA | |
| SCHEMBL7153694 | 0.76 | PTGES (0.37) | PDE5APTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927167-A1 | 2-PHENYL BENZIMIDAZOLE DERIVATIVES AS MCP-1 ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998006703-A1 | 2-PHENYL BENZIMIDAZOLE DERIVATIVES AS MCP-1 ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1998-02-19 | — | — | WO | disclosed |