SCHEMBL8520018

SCHEMBL8520018

CC(=O)CC(=O)NN(NC(=O)CC(C)=O)C(N)=O

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.36
HTT P42858 2/20 0.36
MAPT P10636 2/20 0.33
MGAM O43451 1/20 0.33
GAA P10253 1/20 0.33
SI P14410 1/20 0.33
MGAM2 Q2M2H8 1/20 0.33
ALOX15 P16050 1/20 0.32
BLM P54132 1/20 0.32
PMP22 Q01453 1/20 0.32
KDM4E B2RXH2 2/20 0.32
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2C19 P33261 1/20 0.32
KMT2A Q03164 1/20 0.32
HIF1A Q16665 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA4 P22748 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4449362 0.72 PHF8 (0.52) LMNAHTTMAPTMGAMGAA
SCHEMBL7622688 0.68 KDM4E (0.38) LMNAHTTMAPTMGAMGAA
SCHEMBL2034376 0.68
SCHEMBL28049568 0.68
SCHEMBL7756366 0.68 LMNA (0.39) LMNABLMPMP22ALDH1A1CYP1A2
SCHEMBL3409286 0.67 CRBN (0.52) LMNAHTTMAPTMGAMGAA
SCHEMBL2337827 0.67 CRBN (0.39) LMNAHTTMAPTMGAMGAA
SCHEMBL5134879 0.67 MGAM (0.33) LMNAHTTMAPTMGAMGAA
SCHEMBL7073065 0.67 HSP90AA1 (0.36) LMNAHTTMAPTMGAMGAA
SCHEMBL4105582 0.66

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4229505-A WEAR LAYERS FOR FLOOR COVERINGS ARMSTRONG CORK COMPANY (US) 1980-10-21 US claimed
US-4221902-A CROSSLINKED, WEAR LAYER COATINGS ARMSTRONG CORK COMPANY (US) 1980-09-09 US claimed
US-4218515-A FOR FLOOR COVERINGS HECKLES JOHN S 1980-08-19 US claimed
US-5969046-A USING TERTIARY AMINES AND EPOXIDES AS MAIN ACTIVATOR OF MICHAEL CONDENSATION CURE PROCESS ROHM AND HAAS COMPANY (US) 1999-10-19 US disclosed
EP-0580328-B1 Methacrylate functional polyesters ROHM & HAAS (US) 1997-04-02 EP disclosed
EP-0376590-B1 Monomer or polymer composition derived from acryloxy alkyl cyanoacetamides ROHM & HAAS (US) 1994-11-30 EP disclosed
EP-0580328-A2 Methacrylate functional polyesters ROHM AND HAAS COMPANY (US) 1994-01-26 EP disclosed
EP-0326723-B1 METHOD FOR REACTING TWO COMPONENTS, COMPOSITIONS, COATING COMPOSITIONS AND USES THEREOF ROHM AND HAAS COMPANY (US) 1993-03-24 EP disclosed
US-5021511-A Reacted with carbon-michael addition acceptor; coatings, adhesives, caulks, mastics; nonhydrolyzing ROHM AND HAAS COMPANY (US) 1991-06-04 US disclosed
EP-0376590-A2 Monomer or polymer composition derived from acryloxy alkyl cyanoacetamides ROHM AND HAAS COMPANY (US) 1990-07-04 EP disclosed
EP-0326723-A1 Method for reacting two components, compositions, coating compositions and uses thereof ROHM AND HAAS COMPANY (US) 1989-08-09 EP disclosed
US-4233239-A USED TO MAKE CROSSLINKED COPOLYMERS WITH ACRYLATES AND DIACETOACETAMIDES ARMSTRONG CORK COMPANY (US) 1980-11-11 US disclosed
US-4233239-A USED TO MAKE CROSSLINKED COPOLYMERS WITH ACRYLATES AND DIACETOACETAMIDES ARMSTRONG CORK COMPANY (US) 1980-11-11 US disclosed
US-4229505-A WEAR LAYERS FOR FLOOR COVERINGS ARMSTRONG CORK COMPANY (US) 1980-10-21 US disclosed
US-4229505-A WEAR LAYERS FOR FLOOR COVERINGS ARMSTRONG CORK COMPANY (US) 1980-10-21 US disclosed
US-4221902-A CROSSLINKED, WEAR LAYER COATINGS ARMSTRONG CORK COMPANY (US) 1980-09-09 US disclosed
US-4221902-A CROSSLINKED, WEAR LAYER COATINGS ARMSTRONG CORK COMPANY (US) 1980-09-09 US disclosed
US-4218515-A FOR FLOOR COVERINGS HECKLES JOHN S 1980-08-19 US disclosed
US-4218515-A FOR FLOOR COVERINGS HECKLES JOHN S 1980-08-19 US disclosed