Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | PER2 | O15055 | 2/20 | 0.38 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8411315 | 0.91 | MEN1 (0.56) | MEN1NPC1RAB9AKMT2ACYP2D6 | |
| SCHEMBL6362002 | 0.76 | NPC1 (0.82) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL11036674 | 0.74 | MEN1 (0.55) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL8026728 | 0.74 | MEN1 (0.64) | MEN1NPC1RAB9AKMT2ADRD2 | |
| SCHEMBL6362778 | 0.72 | MEN1 (0.61) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL8397598 | 0.71 | MEN1 (0.50) | MEN1NPC1RAB9AKMT2ACYP2D6 | |
| SCHEMBL4515174 | 0.70 | KMT2A (0.58) | MEN1NPC1RAB9AKMT2ACYP2D6 | |
| SCHEMBL8520034 | 0.69 | RAB9A (0.40) | MEN1NPC1RAB9AKMT2ACYP2D6 | |
| SCHEMBL14019897 | 0.69 | MEN1 (0.51) | MEN1NPC1RAB9AKMT2ACYP2D6 | |
| SCHEMBL909200 | 0.68 | MEN1 (0.61) | MEN1NPC1RAB9AKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932598-A1 | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1999-08-04 | — | — | EP | disclosed |
| WO-1998016502-A1 | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |