Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8520030 | 0.91 | MEN1 (0.49) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL8026728 | 0.83 | MEN1 (0.64) | MEN1NPC1RAB9AKMT2ADDB1 | |
| SCHEMBL4515174 | 0.79 | KMT2A (0.58) | MEN1NPC1RAB9AKMT2ADRD2 | |
| SCHEMBL11036674 | 0.76 | MEN1 (0.55) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL610584 | 0.74 | NPC1 (1.00) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL11036717 | 0.73 | MEN1 (0.50) | MEN1NPC1RAB9AKMT2ADDB1 | |
| SCHEMBL10887685 | 0.72 | MEN1 (0.58) | MEN1NPC1RAB9AKMT2ADDB1 | |
| SCHEMBL30165841 | 0.72 | MEN1 (0.49) | MEN1NPC1RAB9AKMT2ADRD2 | |
| SCHEMBL11861565 | 0.71 | KMT2A (0.62) | MEN1NPC1RAB9AKMT2ADRD2 | |
| SCHEMBL13114923 | 0.71 | LMNA (0.47) | MEN1NPC1RAB9AKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932598-A1 | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1999-08-04 | — | — | EP | disclosed |
| WO-1998016502-A1 | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |