SCHEMBL8520118

SCHEMBL8520118

NC(=O)Cc1cccc(Oc2ccc3cc(O)ccc3c2)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F10 P00742 1/20 0.46
CA2 P00918 1/20 0.45
PLA2G10 O15496 1/20 0.44
FFAR1 O14842 5/20 0.41
KMT2A Q03164 2/20 0.41
FFAR4 Q5NUL3 1/20 0.41
MEN1 O00255 1/20 0.41
CASP3 P42574 1/20 0.41
SENP8 Q96LD8 1/20 0.41
SENP7 Q9BQF6 1/20 0.41
SENP6 Q9GZR1 1/20 0.41
TNKS O95271 1/20 0.41
PARP15 Q460N3 1/20 0.41
PARP14 Q460N5 1/20 0.41
PARP10 Q53GL7 1/20 0.41
TNKS2 Q9H2K2 1/20 0.41
PARP2 Q9UGN5 1/20 0.41
ESR1 P03372 1/20 0.39
FAAH O00519 1/20 0.39
MAOB P27338 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8599783 0.88 SIRT2 (0.49) F10FFAR1KMT2AFFAR4MEN1
SCHEMBL1395777 0.82 FFAR1 (0.56) F10FFAR1FFAR4PARP10FAAH
SCHEMBL7558282 0.81 FFAR1 (0.55) F10FFAR1FFAR4TNKSPARP15
SCHEMBL4672727 0.80 CA2 (0.64) CA2
SCHEMBL2901606 0.78 CYP1A2 (0.54) F10KMT2AMEN1CASP3SENP8
SCHEMBL5282643 0.77 F10 (0.48) F10FFAR1TNKSPARP15PARP14
SCHEMBL1515570 0.76 CA2 (0.57) CA2KMT2A
SCHEMBL10014247 0.74 ESR1 (0.57) KMT2AMEN1ESR1
SCHEMBL1326762 0.73 CTBP2 (0.60) KMT2AMEN1
SCHEMBL5858885 0.73 CA2 (0.77) CA2KMT2AMEN1PARP10ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0763523-B1 NAPHTHALENE DERIVATIVE TEIJIN LTD (JP) 1999-10-13 EP disclosed