Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.45 |
| ▸ | CCR8 | P51685 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | BRS3 | P32247 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.42 |
| ▸ | PRKACA | P17612 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1395777 | 0.87 | FFAR1 (0.56) | F10FFAR1FAAHPARP10PTGES | |
| SCHEMBL7558282 | 0.83 | FFAR1 (0.55) | F10FFAR1FAAHTNKSPARP15 | |
| SCHEMBL15154989 | 0.80 | F10 (0.45) | F10BRS3 | |
| SCHEMBL100121 | 0.79 | LOXL2 (0.52) | F10LMNASMN1; SMN2 | |
| SCHEMBL8599783 | 0.79 | SIRT2 (0.49) | F10FFAR1FAAHTNKSPARP15 | |
| SCHEMBL8520118 | 0.77 | F10 (0.46) | F10FFAR1FAAHTNKSPARP15 | |
| SCHEMBL6204785 | 0.76 | TAAR1 (0.57) | SMN1; SMN2 | |
| SCHEMBL1326762 | 0.76 | CTBP2 (0.60) | HTTMMP13SMN1; SMN2 | |
| SCHEMBL16301337 | 0.76 | ALDH1A1 (0.45) | LMNAHTTSMN1; SMN2 | |
| SCHEMBL6754441 | 0.74 | NR1H3 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006033844-A9 | 4-ARYLSPIROCYCLOALKYL-2-AMINOPYRIMIDINE CARBOXAMIDE KCNQ POTASSIUM CHANNEL MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2007-10-25 | — | — | WO | disclosed |