Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of (Z)-1,2-Diphenylethene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 2/20 | 0.52 |
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | TNKS | O95271 | 1/20 | 0.54 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (Z)-1,2-Diphenylethene SCHEMBL8520705 | 1.00 | LMNA (0.54) | LMNAHDAC1ALDH1A1HDAC3HDAC4 | |
| (Z)-1,2-Diphenylethene SCHEMBL28205397 | 0.90 | MAOB (0.52) | LMNAHDAC1ALDH1A1HDAC3HDAC4 | |
| (E)-4-Styrylphenol SCHEMBL3991876 | 0.89 | CYP3A4 (0.56) | LMNAALDH1A1HDAC6HCAR2CYP1A2 | |
| Sulfuric Acid SCHEMBL30522464 | 0.87 | LMNA (0.48) | LMNAHDAC1ALDH1A1HDAC3HDAC4 | |
| (Z)-1,2-Diphenylethene SCHEMBL11331699 | 0.85 | LMNA (0.47) | LMNAHDAC1ALDH1A1HDAC3HDAC4 | |
| Sulfuric Acid SCHEMBL713714 | 0.85 | GLA (0.48) | LMNAHDAC1ALDH1A1HDAC3HDAC4 | |
| Sulfuric Acid SCHEMBL28843822 | 0.85 | LMNA (0.46) | LMNAHDAC1ALDH1A1HDAC3HDAC4 | |
| (Z)-1,2-Diphenylethene SCHEMBL11331703 | 0.85 | LMNA (0.47) | LMNAHDAC1ALDH1A1HDAC3HDAC4 | |
| Sulfuric Acid SCHEMBL28860891 | 0.85 | LMNA (0.46) | LMNAHDAC1ALDH1A1HDAC3HDAC4 | |
| (Z)-1,2-Diphenylethene SCHEMBL29134000 | 0.85 | MAOB (0.69) | LMNAHDAC1ALDH1A1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5932614-A | VIRICIDES AGAINST HIV | MERRELL PHARMACEUTICALS INC. (US) | 1999-08-03 | — | — | US | disclosed |
| US-5672625-A | Sulfonic stilbene derivatives in the treatment of viral diseases | MERRELL PHARMACEUTICALS INC. (US) | 1997-09-30 | — | — | US | disclosed |
| US-5494932-A | AIDS, RETROVIRUSES, HERPES VIRUSES, CYTOMEGALOVIRUS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-27 | — | — | US | disclosed |
| EP-0498095-B1 | Sulfonic stilbene derivatives in the treatment of viral diseases | MERRELL DOW PHARMA (US) | 1995-01-04 | — | — | EP | disclosed |
| EP-0498095-A1 | Sulfonic stilbene derivatives in the treatment of viral diseases | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-08-12 | — | — | EP | disclosed |