Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aniline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.69 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aniline SCHEMBL4894770 | 1.00 | TSHR (0.69) | TSHRPBRM1CYP3A4TDP1HSD17B10 | |
| Aniline SCHEMBL29429766 | 1.00 | TSHR (0.69) | TSHRPBRM1CYP3A4TDP1HSD17B10 | |
| Aniline SCHEMBL8413315 | 0.90 | TSHR (0.73) | TSHRPBRM1CYP3A4TDP1HSD17B10 | |
| Aniline SCHEMBL6049858 | 0.90 | TSHR (0.73) | TSHRPBRM1CYP3A4TDP1HSD17B10 | |
| Aniline SCHEMBL11591138 | 0.88 | TSHR (0.69) | TSHRPBRM1CYP3A4TDP1HSD17B10 | |
| Aniline SCHEMBL28972529 | 0.88 | TSHR (0.69) | TSHRPBRM1CYP3A4TDP1HSD17B10 | |
| Aniline SCHEMBL27917067 | 0.88 | TSHR (0.69) | TSHRPBRM1CYP3A4TDP1HSD17B10 | |
| Aniline SCHEMBL28806315 | 0.88 | TSHR (0.69) | TSHRPBRM1CYP3A4TDP1HSD17B10 | |
| Oxalic Acid SCHEMBL6915099 | 0.87 | MAPT (0.57) | TSHRCYP3A4TDP1HSD17B10TAAR1 | |
| Aniline SCHEMBL22528486 | 0.87 | TSHR (0.92) | TSHRPBRM1CYP3A4TDP1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114409964-A | Modified nano silicon dioxide and application thereof in preparation of PET packing belt | 江苏坤腾包装有限公司 | 2022-04-29 | — | — | CN | disclosed |
| US-20200179254-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2020-06-11 | — | — | US | disclosed |
| US-20190240129-A1 | CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2019-08-08 | — | — | US | disclosed |
| EP-3518878-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | Henkel AG & Co. KGaA (DE) | 2019-08-07 | — | — | EP | disclosed |
| US-20190216703-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2019-07-18 | — | — | US | disclosed |
| US-20190216714-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2019-07-18 | — | — | US | disclosed |
| EP-2716678-B1 | SOLID PHASE POLYMERIZATION METHOD FOR PREPARING HIGH MOLECULAR WEIGHT ALIPHATIC POLYESTER | NATUREWORKS LLC (US) | 2018-04-25 | — | — | EP | disclosed |
| US-9290616-B2 | Solid-phase polymerization method for preparing high-molecular-weight aliphatic polyester | TORAY INDUSTRIES, INC. (JP) | 2016-03-22 | — | — | US | disclosed |
| US-20140100350-A1 | SOLID-PHASE POLYMERIZATION METHOD FOR PREPARING HIGH-MOLECULAR-WEIGHT ALIPHATIC POLYESTER | TORAY INDUSTRIES, INC. (JP) | 2014-04-10 | — | — | US | disclosed |
| US-5948866-A | BLEND CONTAINING ADDITION POLYMER | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1999-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190240129-A1 | CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, CUTA, S100A10 | TSHR 3146/4885PBRM1 1487/4885CYP3A4 4811/4885 |
| US-20190216703-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, SRRM2, IK | TSHR 1850/4885PBRM1 2736/4885CYP3A4 4841/4885 |
| US-20190216714-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, CD44, PCNA | TSHR 3345/4885PBRM1 1573/4885CYP3A4 4837/4885 |
| US-20200179254-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, CUTA, DSG1 | TSHR 2235/4885PBRM1 405/4885CYP3A4 4500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.