Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 15/20 | 0.60 |
| ▸ | MMP13 | P45452 | 14/20 | 0.60 |
| ▸ | MMP1 | P03956 | 12/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.49 |
| ▸ | PTGES | O14684 | 1/20 | 0.49 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.49 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.49 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6558860 | 0.98 | MMP9 (0.62) | MMP9MMP13MMP1NR3C1PGR | |
| SCHEMBL8521983 | 0.91 | MMP9 (0.58) | MMP9MMP13MMP1NR3C1PGR | |
| SCHEMBL6559690 | 0.90 | MMP9 (0.63) | MMP9MMP13MMP1NR3C1PGR | |
| SCHEMBL7467779 | 0.89 | MMP9 (0.78) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL6560148 | 0.84 | MMP9 (0.83) | MMP9MMP13MMP1NR3C1PGR | |
| SCHEMBL7463546 | 0.81 | MMP9 (0.59) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7413282 | 0.81 | MMP9 (0.52) | MMP9MMP13MMP1NR3C1PGR | |
| SCHEMBL7317676 | 0.80 | MMP13 (0.64) | MMP9MMP13MMP1ALDH1A1LMNA | |
| SCHEMBL7351229 | 0.78 | MMP9 (0.81) | MMP9MMP13MMP1NR3C1PGR | |
| Hydroxyamine SCHEMBL8521994 | 0.78 | MMP9 (0.58) | MMP9MMP13MMP1NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934300-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998016520-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |