Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 11/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 4/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.37 |
| ▸ | HTR1D | P28221 | 3/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.37 |
| ▸ | HTR2B | P41595 | 3/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 3/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7401546 | 0.76 | HTR4 (0.41) | HTR4CHRM3HTR2CADRA2CHTR1D | |
| SCHEMBL6227671 | 0.74 | HTR4 (0.60) | HTR4CHRM3HTR2CADRA2CHTR1D | |
| Hydrochloric Acid SCHEMBL6225658 | 0.73 | HTR2C (0.60) | HTR4CHRM3HTR2CADRA2CHTR1D | |
| SCHEMBL7401544 | 0.73 | HTR4 (0.64) | HTR4CHRM3HTR2CADRA2CHTR1D | |
| SCHEMBL7357910 | 0.67 | HTR4 (0.56) | HTR4CHRM3HTR2CADRA2CHTR1D | |
| SCHEMBL7357913 | 0.65 | HTR4 (0.54) | HTR4CHRM3HTR2CADRA2CHTR1D | |
| Hydrochloric Acid SCHEMBL7137041 | 0.65 | HTR3A (0.54) | HTR4CHRM3HTR2CADRA2CHTR1D | |
| SCHEMBL27343665 | 0.64 | CARM1 (0.57) | HTR4CHRM3ADRA2CHTR1DHTR2B | |
| SCHEMBL8692363 | 0.63 | HTR4 (0.47) | HTR4CHRM3HTR2CADRA2CHTR1D | |
| SCHEMBL27762899 | 0.63 | CHRM3 (0.49) | CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604494-B1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-28 | — | — | EP | claimed |