Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.60 |
| ▸ | HTR2A | P28223 | 11/20 | 0.60 |
| ▸ | HTR7 | P34969 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 9/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL85560 | 0.93 | DRD2 (0.58) | DRD2HTR2AHTR7HTR1A | |
| SCHEMBL21987957 | 0.85 | DRD2 (0.57) | DRD2HTR2AHTR7HTR1A | |
| SCHEMBL8853747 | 0.84 | HTR2A (0.64) | DRD2HTR2AHTR7HTR1A | |
| SCHEMBL1545753 | 0.84 | ACHE (0.73) | DRD2HTR2AHTR7 | |
| SCHEMBL84999 | 0.84 | HTR2A (0.64) | DRD2HTR2AHTR7HTR1A | |
| SCHEMBL85011 | 0.83 | DRD2 (0.58) | DRD2HTR2AHTR7HTR1A | |
| SCHEMBL85566 | 0.83 | DRD2 (0.56) | DRD2HTR2AHTR7HTR1A | |
| SCHEMBL10638075 | 0.82 | DRD2 (0.56) | DRD2HTR2AHTR7HTR1A | |
| SCHEMBL21678218 | 0.82 | DRD2 (0.58) | DRD2HTR2AHTR7HTR1A | |
| SCHEMBL22048329 | 0.82 | DRD2 (0.57) | DRD2HTR2AHTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129410-B2 | Sleep maintenance insomnia; circadian rhythm abnormalities; side effect reduction | HYPNION, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| US-8129410-B2 | Sleep maintenance insomnia; circadian rhythm abnormalities; side effect reduction | HYPNION, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| US-20080214539-A1 | Benzisoxazole Piperidine Compounds and Methods of Use Thereof | HYPNION, INC. | 2008-09-04 | — | — | US | disclosed |
| US-20080214539-A1 | Benzisoxazole Piperidine Compounds and Methods of Use Thereof | HYPNION, INC. | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214539-A1 | Benzisoxazole Piperidine Compounds and Methods of Use Thereof | GABRA5, GABRE, HCRTR2 | DRD2 1344/4885HTR2A 284/4885HTR7 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.