Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 7/20 | 0.58 |
| ▸ | PTGER2 | P43116 | 7/20 | 0.58 |
| ▸ | PTGER3 | P43115 | 6/20 | 0.58 |
| ▸ | PTGER1 | P34995 | 5/20 | 0.58 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | CDK4 | P11802 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | CCND1 | P24385 | 1/20 | 0.56 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 2/20 | 0.47 |
| ▸ | RXRB | P28702 | 2/20 | 0.47 |
| ▸ | RXRG | P48443 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8522682 | 1.00 | PTGER4 (0.58) | PTGER4PTGER2PTGER3PTGER1CCNB2 | |
| SCHEMBL8710177 | 0.87 | CCNB2 (0.66) | PTGER4PTGER2PTGER3PTGER1CCNB2 | |
| SCHEMBL8710180 | 0.87 | CCNB2 (0.66) | PTGER4PTGER2PTGER3PTGER1CCNB2 | |
| SCHEMBL8523359 | 0.83 | KMT2A (0.62) | PTGER4PTGER2PTGER3PTGER1CCNB2 | |
| SCHEMBL8523361 | 0.83 | KMT2A (0.62) | PTGER4PTGER2PTGER3PTGER1CCNB2 | |
| SCHEMBL8462141 | 0.77 | NFKB1 (0.49) | CDK4CCND1POLBBLMTDP1 | |
| SCHEMBL9857489 | 0.77 | CCNB2 (0.64) | PTGER4PTGER2PTGER3PTGER1CCNB2 | |
| SCHEMBL9857485 | 0.77 | CCNB2 (0.64) | PTGER4PTGER2PTGER3PTGER1CCNB2 | |
| SCHEMBL7798321 | 0.77 | PTGER4 (0.78) | PTGER4PTGER2PTGER3PTGER1CCNB2 | |
| SCHEMBL7798324 | 0.77 | PTGER4 (0.78) | PTGER4PTGER2PTGER3PTGER1CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |