Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 10/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1507828 | 0.98 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CTAAR1HTR1A | |
| SCHEMBL7853500 | 0.84 | ADRA2A (0.55) | ADRA2AADRA2BADRA2CTAAR1HTR1A | |
| SCHEMBL28103549 | 0.82 | ADRA2A (0.69) | ADRA2AADRA2BADRA2CTAAR1HTR1A | |
| SCHEMBL10417520 | 0.82 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CTAAR1HTR1A | |
| Hydrochloric Acid SCHEMBL1508039 | 0.81 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CTAAR1HTR1A | |
| SCHEMBL11387115 | 0.80 | ALDH1A1 (0.58) | ADRA2AADRA2BADRA2CCYP19A1TSHR | |
| SCHEMBL8051573 | 0.75 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CTAAR1HTR1A | |
| SCHEMBL4018722 | 0.75 | TAAR1 (0.67) | ADRA2AADRA2BADRA2CTAAR1HTR1A | |
| SCHEMBL1509682 | 0.75 | TAAR1 (0.67) | ADRA2AADRA2BADRA2CTAAR1HTR1A | |
| SCHEMBL11568003 | 0.75 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CTAAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0951285-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-10-27 | — | — | EP | disclosed |
| WO-1998029119-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1998-07-09 | — | — | WO | disclosed |