Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | GALR3 | O60755 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11380435 | 0.83 | CYP19A1 (0.58) | ALDH1A1SMN1; SMN2MAPTTSHRNPSR1 | |
| SCHEMBL6755431 | 0.81 | CYP19A1 (0.56) | ALDH1A1SMN1; SMN2TSHRLMNAADRA2A | |
| SCHEMBL11386043 | 0.81 | CYP19A1 (0.45) | ALDH1A1SMN1; SMN2TSHRLMNAHTT | |
| SCHEMBL8522992 | 0.80 | ADRA2A (0.55) | TSHRADRA2AADRA2BADRA2CCYP19A1 | |
| Hydrochloric Acid SCHEMBL1507828 | 0.79 | ADRA2A (0.57) | SMN1; SMN2TSHRLMNAADRA2AADRA2B | |
| SCHEMBL11377432 | 0.77 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CCYP19A1 | |
| SCHEMBL11376946 | 0.76 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CCYP19A1POLB | |
| SCHEMBL11376179 | 0.74 | ADRA2A (0.47) | ADRA2AADRA2BADRA2C | |
| SCHEMBL11382946 | 0.74 | TBXAS1 (0.53) | ALDH1A1ADRA2AADRA2BADRA2CKMT2A | |
| Fumaric Acid SCHEMBL11386887 | 0.74 | LMNA (0.42) | ALDH1A1SMN1; SMN2MAPTTSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4273782-A | FOR USE IN CARDIOVASCULAR DISORDERS AND COMPLICATIONS OF DIABETES | PFIZER INC. (US) | 1981-06-16 | — | — | US | disclosed |