Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFB | P00751 | 6/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23491516 | 0.83 | TRPA1 (0.44) | — | |
| SCHEMBL4949268 | 0.83 | CFB (0.36) | CFBDRD2DRD3 | |
| SCHEMBL29489966 | 0.83 | ATM (0.43) | CFB | |
| SCHEMBL12124887 | 0.83 | CHRNB2 (0.53) | CFB | |
| SCHEMBL22473185 | 0.83 | CHRNB2 (0.53) | CFB | |
| SCHEMBL12128467 | 0.81 | CHRNB2 (0.51) | CFB | |
| SCHEMBL12997532 | 0.81 | CYP19A1 (0.47) | SLC6A4DRD2DRD3 | |
| SCHEMBL6222954 | 0.78 | CFB (0.43) | CFB | |
| SCHEMBL23032155 | 0.78 | DRD2 (0.46) | SLC6A3DRD2 | |
| SCHEMBL20349553 | 0.78 | TRPA1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0593286-B1 | Intermediates for preparing antifolate compounds and processes thereto | LILLY CO ELI (US) | 1999-12-15 | — | — | EP | disclosed |
| US-5969136-A | Cyclization for preparing antifolate compounds | ELI LILLY AND COMPANY (US) | 1999-10-19 | — | — | US | disclosed |
| US-5486614-A | Intermediates for preparing antifolate compounds | ELI LILLY AND COMPANY (US) | 1996-01-23 | — | — | US | disclosed |
| EP-0593286-A2 | Intermediates for preparing antifolate compounds and processes there to | ELI LILLY AND COMPANY (US) | 1994-04-20 | — | — | EP | disclosed |