SCHEMBL8524145

SCHEMBL8524145

C[SiH](C)C1=C(c2ccccc2)[CH]c2ccccc21

nearest known ligand 0.34

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.34
HSD17B10 Q99714 2/20 0.34
HPGD P15428 1/20 0.30
BCL2L1 Q07817 1/20 0.30
CYP2A6 P11509 1/20 0.30
MAPK1 P28482 1/20 0.30
NISCH Q9Y2I1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5611715 0.74 MEN1 (0.34) ALDH1A1HSD17B10HPGD
SCHEMBL216368 0.74 ALDH1A1 (0.38) ALDH1A1HSD17B10HPGDBCL2L1CYP2A6
SCHEMBL7941078 0.71 ALDH1A1 (0.35) ALDH1A1HSD17B10HPGDBCL2L1CYP2A6
SCHEMBL2965426 0.69 CYP2A6 (0.43) ALDH1A1HSD17B10HPGDBCL2L1CYP2A6
SCHEMBL2960805 0.69 ALDH1A1 (0.43) ALDH1A1HSD17B10HPGDBCL2L1CYP2A6
SCHEMBL217176 0.69 ALDH1A1 (0.34) ALDH1A1HSD17B10HPGDBCL2L1CYP2A6
SCHEMBL7923402 0.69 ALDH1A1 (0.34) ALDH1A1HSD17B10HPGDBCL2L1CYP2A6
SCHEMBL1507320 0.68 PDCD1 (0.35) ALDH1A1HSD17B10HPGDBCL2L1CYP2A6
SCHEMBL218029 0.67 ALDH1A1 (0.32) ALDH1A1HSD17B10HPGD
SCHEMBL2973874 0.65 KIF11 (0.38) ALDH1A1HSD17B10HPGDBCL2L1CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0946574-A1 3-ARYL SUBSTITUTED INDENYL CONTAINING METAL COMPLEXES AND POLYMERIZATION PROCESS THE DOW CHEMICAL COMPANY (US) 1999-10-06 EP disclosed
WO-1998027102-A1 3-ARYL SUBSTITUTED INDENYL CONTAINING METAL COMPLEXES AND POLYMERIZATION PROCESS THE DOW CHEMICAL COMPANY (US) 1998-06-25 WO disclosed