Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 4/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.39 |
| ▸ | DTYMK | P23919 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27777004 | 0.85 | P2RX4 (0.39) | POLBGRM5 | |
| SCHEMBL28536825 | 0.83 | LMNA (0.39) | POLBGPR119 | |
| SCHEMBL4064728 | 0.82 | MAPT (0.40) | POLBGRM5GRM1GPR119 | |
| SCHEMBL28984504 | 0.79 | POLB (0.43) | POLBGRM5GRM1GPR119DTYMK | |
| Quinoline SCHEMBL28294326 | 0.79 | PDE10A (0.38) | POLBGRM5GRM1GPR119KDM1A | |
| SCHEMBL5560408 | 0.78 | BCHE (0.46) | GRM5GRM1GPR119MAPK1KDM1A | |
| SCHEMBL29380399 | 0.78 | BCHE (0.46) | GRM5GRM1GPR119MAPK1KDM1A | |
| SCHEMBL1836164 | 0.77 | PARP1 (0.36) | MAPK1 | |
| SCHEMBL30511570 | 0.77 | PARP1 (0.36) | MAPK1 | |
| SCHEMBL29106412 | 0.77 | SMN1; SMN2 (0.33) | TRPA1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117083274-A | Fused ring heterocyclic derivative and application thereof in medicine | 四川海思科制药有限公司 | 2023-11-17 | — | — | CN | disclosed |
| WO-2021083011-A1 | BRIDGED CYCLOFORMYLPYRIDINE DERIVATIVE AND USE THEREOF | 北京伯汇生物技术有限公司 | 2021-05-06 | — | — | WO | disclosed |
| EP-1425010-B8 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | JANSSEN PHARMACEUTICALS INC (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-1425010-B1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | ORTHO MCNEIL PHARM INC (US) | 2011-10-26 | — | — | EP | disclosed |