SCHEMBL8524880

SCHEMBL8524880

C[Si](C)(C)C#Cc1cn(COCC[Si](C)(C)C)c(S(=O)(=O)c2ccccc2)n1

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 4/20 0.34
HTR6 P50406 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8489454 0.74 DGAT1 (0.38) DGAT1HTR6
SCHEMBL8486907 0.70 DGAT1 (0.33) DGAT1
SCHEMBL23063436 0.70 DGAT1 (0.35) DGAT1HTR6
SCHEMBL16188918 0.69 DGAT1 (0.34) DGAT1
SCHEMBL23063047 0.65 DGAT1 (0.35) DGAT1HTR6
SCHEMBL8376148 0.65 C1S (0.40)
SCHEMBL8372860 0.65 NR1I2 (0.41)
SCHEMBL14655267 0.65 DGAT1 (0.34) DGAT1
SCHEMBL31055997 0.64
SCHEMBL14498912 0.62 NPC1 (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999006377-A1 DERIVATIVES OF 1-((3,3-DIMETHYL-3-SILABUTOXY)METHYL)-2-(PHENYLSULFONYL)IMIDAZOLE GLIATECH, INC. (US) 1999-02-11 WO disclosed