Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 known ✓ | P22460 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.35 |
| ▸ | CTSD | P07339 | 3/20 | 0.33 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8476718 | 0.95 | TRPV1 (0.38) | TRPV1CTSDBACE1BACE2SIRT2 | |
| SCHEMBL8476969 | 0.87 | TRPV1 (0.36) | TRPV1CTSDBACE1BACE2L3MBTL1 | |
| Hydrochloric Acid SCHEMBL8525592 | 0.76 | TRPV1 (0.34) | TRPV1CTSDBACE1BACE2SIRT2 | |
| SCHEMBL8476723 | 0.75 | TRPV1 (0.38) | TRPV1CTSDBACE1BACE2SIRT2 | |
| SCHEMBL8480828 | 0.73 | TRPV1 (0.47) | TRPV1CTSDBACE1 | |
| SCHEMBL6559916 | 0.69 | TRPV1 (0.42) | TRPV1SIRT2SIRT1KCNA5 | |
| SCHEMBL6558641 | 0.67 | TRPV1 (0.39) | TRPV1CTSDBACE1BACE2SIRT2 | |
| SCHEMBL9789599 | 0.66 | TRPV1 (0.44) | TRPV1SIRT2SIRT1 | |
| SCHEMBL9581927 | 0.66 | TRPV1 (0.44) | TRPV1SIRT2SIRT1 | |
| SCHEMBL8480422 | 0.64 | TRPV1 (0.50) | TRPV1CTSDBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955607-A | TREATING CARDIOVASCULAR AND GASTROINTESTINAL DISORDERS | HOECHST MARION ROUSSEL DEUTSCHLAND (DE) | 1999-09-21 | — | — | US | disclosed |