Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 13/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6558641 | 0.87 | TRPV1 (0.39) | TRPV1KCNA5SIRT2HTTSIRT1 | |
| SCHEMBL6559538 | 0.83 | TRPV1 (0.37) | TRPV1KCNA5SIRT2CYP3A4 | |
| SCHEMBL6559262 | 0.80 | TRPV1 (0.43) | TRPV1KCNA5SIRT2SIRT1 | |
| SCHEMBL23423341 | 0.80 | KMT2A (0.44) | TRPV1SIRT2SIRT1CYP3A4HTR1A | |
| SCHEMBL7464900 | 0.78 | KCNE1 (0.52) | TRPV1SIRT2 | |
| SCHEMBL6603299 | 0.76 | KCNE1 (0.54) | TRPV1HTTHTR2BSIGMAR1 | |
| SCHEMBL9581927 | 0.74 | TRPV1 (0.44) | TRPV1SIRT2SIRT1CYP3A4 | |
| SCHEMBL9789599 | 0.74 | TRPV1 (0.44) | TRPV1SIRT2SIRT1CYP3A4 | |
| SCHEMBL10583842 | 0.74 | FFAR4 (0.56) | TRPV1KCNA5HTTCYP3A4 | |
| SCHEMBL10584290 | 0.74 | ALDH1A1 (0.44) | TRPV1KCNA5HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| US-5955607-A | TREATING CARDIOVASCULAR AND GASTROINTESTINAL DISORDERS | HOECHST MARION ROUSSEL DEUTSCHLAND (DE) | 1999-09-21 | — | — | US | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |