SCHEMBL8525385

SCHEMBL8525385

[CH2]C(Cc1ccccc1)Oc1cccc2[nH]ncc12

nearest known ligand 0.56

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 8/20 0.56
DRD2 P14416 1/20 0.52
DRD4 P21917 1/20 0.52
DRD3 P35462 1/20 0.52
METAP2 P50579 3/20 0.47
NOS1 P29475 4/20 0.40
AXL P30530 2/20 0.40
ROCK2 O75116 1/20 0.37
ARHGDIA P52565 1/20 0.37
ROCK1 Q13464 1/20 0.37
BRD4 O60885 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1142167 0.76 DRD2 (0.65) IDO1DRD2DRD4DRD3METAP2
SCHEMBL30481265 0.76 DRD2 (0.65) IDO1DRD2DRD4DRD3METAP2
SCHEMBL26131401 0.73 IDO1 (0.50) IDO1DRD2DRD4DRD3METAP2
SCHEMBL8487957 0.71 IDO1 (0.47) IDO1DRD2DRD4DRD3METAP2
SCHEMBL28199257 0.70 NOS1 (0.57) IDO1DRD2DRD4DRD3METAP2
SCHEMBL8525383 0.70 DRD2 (0.58) IDO1DRD2DRD4DRD3METAP2
SCHEMBL8612003 0.68 DRD4 (1.00) DRD2DRD4DRD3
SCHEMBL3471094 0.68 BRD4 (0.60) IDO1DRD2DRD4DRD3METAP2
SCHEMBL30425937 0.68 BRD4 (0.60) IDO1DRD2DRD4DRD3METAP2
SCHEMBL17738298 0.67 DRD4 (0.51) IDO1DRD2DRD4DRD3METAP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5872144-A DOPAMINERGIC AGENTS USEFUL IN THE TREATMENT OF SCHIZOPHRENIA, TOURETTE'S SYNDROME, DRUG AND ALCOHOL ADDICTION, AND ALSO USEFUL IN THE TREATMENT OF PARKINSON'S DISEASE. AMERICAN HOME PRODUCTS CORPORATION (US) 1999-02-16 US claimed
US-5872144-A DOPAMINERGIC AGENTS USEFUL IN THE TREATMENT OF SCHIZOPHRENIA, TOURETTE'S SYNDROME, DRUG AND ALCOHOL ADDICTION, AND ALSO USEFUL IN THE TREATMENT OF PARKINSON'S DISEASE. AMERICAN HOME PRODUCTS CORPORATION (US) 1999-02-16 US disclosed