Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 16/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 16/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 16/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 16/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8525581 | 1.00 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DAKR1C2 | |
| SCHEMBL4818722 | 0.93 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DAKR1C2 | |
| SCHEMBL4818718 | 0.93 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DAKR1C2 | |
| SCHEMBL5077492 | 0.86 | ALDH1A1 (0.61) | AKR1C2ALDH1A1GAAMAPTCYP1A2 | |
| SCHEMBL10848469 | 0.78 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL10848465 | 0.78 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL28816702 | 0.78 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL13984813 | 0.77 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13986023 | 0.77 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4824892 | 0.76 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0918746-A1 | IMMUNOTHERAPEUTIC AGENTS AND THEIR USE IN THE REDUCTION OF CYTOKINE LEVELS | CELGENE CORPORATION (US) | 1999-06-02 | — | — | EP | disclosed |
| WO-1998006692-A1 | NOVEL IMMUNOTHERAPEUTIC AGENTS AND THEIR USE IN THE REDUCTION OF CYTOKINE LEVELS | CELGENE CORPORATION (US) | 1998-02-19 | — | — | WO | disclosed |