Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL214946 | 0.94 | ALDH1A1 (0.56) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL6297284 | 0.84 | MAPT (0.54) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL1061802 | 0.83 | MAPT (0.56) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL29502955 | 0.83 | MAPT (0.56) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL861015 | 0.82 | ALDH1A1 (0.46) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| Ammonia Solution, Strong SCHEMBL28855632 | 0.81 | MAPT (0.55) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL8127404 | 0.80 | KDM4E (0.59) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL7407827 | 0.80 | CTSV (0.49) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL10870559 | 0.80 | MAPT (0.71) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL11747357 | 0.80 | MAPT (0.61) | ALDH1A1KDM4EMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425010-B8 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | JANSSEN PHARMACEUTICALS INC (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-1425010-A4 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | ORTHO MCNEIL PHARM INC (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-1425010-A1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2002060438-A1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2002-08-08 | — | — | WO | disclosed |