Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CTSV | O60911 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL214946 | 0.87 | ALDH1A1 (0.56) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL2489895 | 0.84 | LTA4H (0.51) | ALDH1A1KDM4EMAPK1MAPTSMN1; SMN2 | |
| SCHEMBL852570 | 0.82 | ALDH1A1 (0.54) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL6297284 | 0.79 | MAPT (0.54) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL29502955 | 0.77 | MAPT (0.56) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL1061802 | 0.77 | MAPT (0.56) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| Ammonia Solution, Strong SCHEMBL28855632 | 0.76 | MAPT (0.55) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL8127404 | 0.75 | KDM4E (0.59) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL10870559 | 0.74 | MAPT (0.71) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL11747357 | 0.74 | MAPT (0.61) | ALDH1A1KDM4EMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425010-B8 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | JANSSEN PHARMACEUTICALS INC (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-1425010-A4 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | ORTHO MCNEIL PHARM INC (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-1425010-A1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2002060438-A1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2002-08-08 | — | — | WO | disclosed |