Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 9/20 | 0.41 |
| ▸ | ITGAV | P06756 | 9/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.37 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PTGIR | P43119 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8500892 | 0.81 | PTGDR2 (0.35) | PTGDR2ALDH1A1POLB | |
| SCHEMBL8526327 | 0.77 | ITGB3 (0.49) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL6798729 | 0.71 | ITGB3 (0.44) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7785708 | 0.68 | ITGB3 (0.53) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL8501256 | 0.67 | KMT2A (0.33) | PTGDR2POLB | |
| SCHEMBL7997106 | 0.66 | ITGB3 (0.70) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7856513 | 0.66 | ITGB3 (0.45) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL8532462 | 0.65 | ITGB3 (0.43) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7367300 | 0.64 | ITGB3 (0.51) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL8532458 | 0.63 | ITGB3 (0.40) | ITGB3ITGAVITGA2BITGB1ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | claimed |
| WO-1997036862-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |