Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | FABP1 | P07148 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.32 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501256 | 0.85 | KMT2A (0.33) | PTGDR2GAAPOLBKMT2AMAPT | |
| SCHEMBL8525879 | 0.81 | ITGB3 (0.41) | PTGDR2POLBALDH1A1 | |
| SCHEMBL8498404 | 0.80 | PPARG (0.43) | MAPTHPGDLMNA | |
| SCHEMBL8502800 | 0.76 | MAPT (0.33) | PTGDR2GAAKMT2AMAPTPFKFB3 | |
| SCHEMBL7376815 | 0.75 | ALDH1A1 (0.55) | POLBKMT2AMAPTMEN1LMNA | |
| SCHEMBL8501758 | 0.74 | HTR6 (0.43) | POLBKMT2AMAPTPFKFB3MEN1 | |
| SCHEMBL8499997 | 0.73 | PFKFB3 (0.41) | PTGDR2KMT2AMAPTPFKFB3MEN1 | |
| SCHEMBL8501524 | 0.71 | PFKFB3 (0.47) | PTGDR2KMT2AMAPTPFKFB3MEN1 | |
| SCHEMBL8500104 | 0.71 | CA1 (0.32) | POLBPFKFB3FABP1HTR6CA1 | |
| SCHEMBL8500583 | 0.71 | PFKFB3 (0.39) | PTGDR2KMT2AMAPTPFKFB3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | claimed |
| WO-1997036862-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |