Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | ALPL | P05186 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | F2 | P00734 | 2/20 | 0.46 |
| ▸ | F12 | P00748 | 2/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8525369 | 0.86 | NPC1 (0.49) | NPC1RAB9AL3MBTL1SMN1; SMN2TDP1 | |
| SCHEMBL8525540 | 0.79 | NPC1 (0.50) | NPC1RAB9AL3MBTL1SMN1; SMN2TDP1 | |
| SCHEMBL8524775 | 0.75 | NPC1 (0.63) | NPC1RAB9AL3MBTL1SMN1; SMN2TDP1 | |
| SCHEMBL30030958 | 0.73 | NPC1 (0.66) | NPC1RAB9AL3MBTL1SMN1; SMN2TDP1 | |
| SCHEMBL2003184 | 0.73 | NPC1 (0.66) | NPC1RAB9AL3MBTL1SMN1; SMN2TDP1 | |
| SCHEMBL8525086 | 0.72 | RAB9A (0.60) | NPC1RAB9AL3MBTL1SMN1; SMN2TDP1 | |
| SCHEMBL17321504 | 0.72 | NPC1 (0.53) | NPC1RAB9AL3MBTL1SMN1; SMN2TDP1 | |
| SCHEMBL8524984 | 0.72 | KDM4E (0.49) | NPC1RAB9AL3MBTL1SMN1; SMN2TDP1 | |
| SCHEMBL8525257 | 0.72 | SMN1; SMN2 (0.49) | NPC1RAB9AL3MBTL1SMN1; SMN2TDP1 | |
| SCHEMBL18112556 | 0.72 | NPC1 (0.55) | NPC1RAB9AL3MBTL1SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999007352-A2 | METHOD FOR PROMOTING EXPRESSION OF LDL RECEPTOR GENE | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-02-18 | — | — | WO | claimed |
| WO-1999007352-A2 | METHOD FOR PROMOTING EXPRESSION OF LDL RECEPTOR GENE | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-02-18 | — | — | WO | disclosed |