Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.65 |
| ▸ | DRD3 | P35462 | 8/20 | 0.65 |
| ▸ | DRD4 | P21917 | 6/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.63 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | DRD1 | P21728 | 1/20 | 0.61 |
| ▸ | CA4 | P22748 | 1/20 | 0.61 |
| ▸ | CA6 | P23280 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | CA5A | P35218 | 1/20 | 0.61 |
| ▸ | CA7 | P43166 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8527005 | 0.90 | SIGMAR1 (0.68) | DRD2DRD3DRD4SIGMAR1DRD1 | |
| Hydrochloric Acid SCHEMBL9091536 | 0.89 | SIGMAR1 (0.67) | DRD2DRD3DRD4SIGMAR1DRD1 | |
| SCHEMBL8526450 | 0.87 | DRD3 (0.68) | DRD2DRD3DRD4SIGMAR1DRD1 | |
| SCHEMBL8528423 | 0.87 | SIGMAR1 (0.81) | DRD2DRD3SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL8528369 | 0.87 | DRD3 (0.76) | DRD2DRD3DRD4SIGMAR1CA12 | |
| SCHEMBL8526374 | 0.86 | DRD2 (0.61) | DRD2DRD3DRD4SIGMAR1CA12 | |
| SCHEMBL8526543 | 0.79 | DRD3 (0.68) | DRD2DRD3SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL10355478 | 0.79 | DRD2 (1.00) | DRD2DRD3DRD4CA12CA1 | |
| SCHEMBL27678962 | 0.79 | DRD2 (1.00) | DRD2DRD3DRD4CA12CA1 | |
| SCHEMBL10355479 | 0.79 | DRD2 (1.00) | DRD2DRD3DRD4CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539281-A1 | New naphthamides, process for their preparation and their application in the therapeutical field | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1993-04-28 | — | — | EP | claimed |
| EP-0539281-B1 | Naphthamides, process for their preparation and their application in the therapeutical field | INST NAT SANTE RECH MED (FR) | 1998-12-30 | — | — | EP | disclosed |
| US-5498628-A | ANTIPSYCHOTIC, PSYCHOSTIMULATORY, ANTIAUTISTIC, ANTIDEPRESSANT AND HYPOTENSIVE AGENTS, PARKINSON'S DISEASE | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-03-12 | — | — | US | disclosed |
| EP-0539281-A1 | New naphthamides, process for their preparation and their application in the therapeutical field | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1993-04-28 | — | — | EP | disclosed |