Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.68 |
| ▸ | DRD2 | P14416 | 7/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | DRD3 | P35462 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | DRD1 | P21728 | 1/20 | 0.63 |
| ▸ | DRD4 | P21917 | 1/20 | 0.63 |
| ▸ | DRD5 | P21918 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9091536 | 0.99 | SIGMAR1 (0.67) | SIGMAR1DRD2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL8526450 | 0.93 | DRD3 (0.68) | SIGMAR1DRD2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL8528423 | 0.91 | SIGMAR1 (0.81) | SIGMAR1DRD2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL8526014 | 0.90 | DRD2 (0.65) | SIGMAR1DRD2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL8526543 | 0.89 | DRD3 (0.68) | SIGMAR1DRD2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL8527031 | 0.88 | SIGMAR1 (0.82) | SIGMAR1DRD2DRD3 | |
| SCHEMBL8527239 | 0.88 | SIGMAR1 (0.65) | SIGMAR1DRD2KDM4ECYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL9088683 | 0.88 | DRD3 (0.67) | SIGMAR1DRD2KDM4ECYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL9092327 | 0.87 | SIGMAR1 (0.81) | SIGMAR1DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9091200 | 0.87 | SIGMAR1 (0.64) | SIGMAR1DRD2KDM4ECYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539281-B1 | Naphthamides, process for their preparation and their application in the therapeutical field | INST NAT SANTE RECH MED (FR) | 1998-12-30 | — | — | EP | claimed |
| EP-0539281-A1 | New naphthamides, process for their preparation and their application in the therapeutical field | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1993-04-28 | — | — | EP | claimed |
| EP-0539281-B1 | Naphthamides, process for their preparation and their application in the therapeutical field | INST NAT SANTE RECH MED (FR) | 1998-12-30 | — | — | EP | disclosed |
| US-5498628-A | ANTIPSYCHOTIC, PSYCHOSTIMULATORY, ANTIAUTISTIC, ANTIDEPRESSANT AND HYPOTENSIVE AGENTS, PARKINSON'S DISEASE | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-03-12 | — | — | US | disclosed |
| EP-0539281-A1 | New naphthamides, process for their preparation and their application in the therapeutical field | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1993-04-28 | — | — | EP | disclosed |