Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 13/20 | 0.38 |
| ▸ | F2 | P00734 | 6/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7058207 | 0.91 | PRSS1 (0.41) | PLAUPRSS1PRSS2PRSS3TRPM8 | |
| SCHEMBL6900983 | 0.91 | PRSS1 (0.41) | PLAUPRSS1PRSS2PRSS3TRPM8 | |
| Hydrochloric Acid SCHEMBL8122656 | 0.90 | PRSS1 (0.40) | PLAUPRSS1PRSS2PRSS3TRPM8 | |
| SCHEMBL1389004 | 0.88 | F10 (0.44) | PRSS1PRSS2PRSS3F10F2 | |
| SCHEMBL8526765 | 0.88 | F10 (0.45) | PRSS1PRSS2PRSS3F10F2 | |
| Hydrochloric Acid SCHEMBL8121834 | 0.87 | F10 (0.43) | PRSS1PRSS2PRSS3F10F2 | |
| SCHEMBL7751908 | 0.85 | PRSS1 (0.39) | PLAUPRSS1PRSS2PRSS3TRPM8 | |
| Hydrochloric Acid SCHEMBL8119247 | 0.85 | PRSS1 (0.39) | PLAUPRSS1PRSS2PRSS3TRPM8 | |
| SCHEMBL8528339 | 0.83 | CNR1 (0.40) | NR1H3 | |
| SCHEMBL1389096 | 0.83 | F10 (0.43) | PLAUPRSS1PRSS2PRSS3F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885186-A1 | AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997019911-A1 | AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1997-06-05 | — | — | WO | disclosed |