SCHEMBL8526418

SCHEMBL8526418

NCCC[C@H](N)C(=O)NCc1ccccc1

nearest known ligand 0.70

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 1/20 0.64
LTA4H P09960 1/20 0.51
CYP1A2 P05177 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C9 P11712 1/20 0.50
TSHR P16473 1/20 0.50
CYP2C19 P33261 1/20 0.50
SPHK1 Q9NYA1 1/20 0.49
MMP8 P22894 2/20 0.49
EGFR P00533 2/20 0.48
SRC P12931 1/20 0.48
SLC1A1 P43005 1/20 0.48
KMT2A Q03164 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
GAA P10253 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9275540 1.00 MMP2 (0.64) MMP2LTA4HCYP1A2CYP2D6CYP2C9
SCHEMBL8691002 0.95 MMP2 (0.71) MMP2LTA4HCYP1A2CYP2D6CYP2C9
SCHEMBL3907033 0.95 MMP2 (0.71) MMP2LTA4HCYP1A2CYP2D6CYP2C9
SCHEMBL30120748 0.90 MMP2 (0.56) MMP2CYP1A2CYP2D6CYP2C9TSHR
SCHEMBL3583374 0.90 MMP2 (0.56) MMP2CYP1A2CYP2D6CYP2C9TSHR
Hydrochloric Acid SCHEMBL28736783 0.89 MMP2 (0.55) MMP2CYP1A2CYP2D6CYP2C9TSHR
SCHEMBL16150370 0.86 MMP2 (0.56) MMP2SPHK1MMP8EGFRSRC
SCHEMBL16103702 0.86 MMP2 (0.52) MMP2CYP2D6SPHK1MMP8EGFR
SCHEMBL16150371 0.86 MMP2 (0.56) MMP2SPHK1MMP8EGFRSRC
SCHEMBL13151621 0.86 MMP2 (0.52) MMP2CYP2D6SPHK1MMP8EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0885186-A1 AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR PREPARING THEM Dr. Karl Thomae GmbH (DE) 1998-12-23 EP disclosed
WO-1997019911-A1 AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR PREPARING THEM DR. KARL THOMAE GMBH (DE) 1997-06-05 WO disclosed
EP-0680469-A1 AMINOACID DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND PROCESS FOR PREPARING THE SAME Dr. Karl Thomae GmbH (DE) 1995-11-08 EP disclosed
WO-1994017035-A1 AMINOACID DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND PROCESS FOR PREPARING THE SAME DR. KARL THOMAE GMBH (DE) 1994-08-04 WO disclosed