Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MC4R | P32245 | 1/20 | 0.49 |
| ▸ | SCN4A | P35499 | 1/20 | 0.49 |
| ▸ | MC3R | P41968 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8609192 | 0.92 | ALDH1A1 (0.50) | ALDH1A1MAPTPOLBALOX12KMT2A | |
| SCHEMBL8526136 | 0.91 | GAA (0.47) | ALDH1A1GAAMAPTLMNACYP3A4 | |
| SCHEMBL8527630 | 0.84 | CYP1A2 (0.49) | ALDH1A1GAAMAPTLMNACYP3A4 | |
| SCHEMBL8582040 | 0.78 | HTT (0.43) | ALDH1A1LMNAALDH2ABCC1CYP2C19 | |
| SCHEMBL8686241 | 0.76 | POLB (0.49) | ALDH1A1GAAMAPTLMNACYP3A4 | |
| SCHEMBL8684948 | 0.75 | ABCC1 (0.57) | ALDH1A1GAACYP3A4ALDH2ABCC1 | |
| SCHEMBL8582414 | 0.75 | SMN1; SMN2 (0.49) | ALDH1A1MAPTLMNAMAPK1POLB | |
| SCHEMBL8687123 | 0.75 | POLB (0.54) | ALDH1A1GAAMAPTLMNAMAPK1 | |
| SCHEMBL11263846 | 0.74 | ALDH1A1 (0.53) | ALDH1A1GAAMAPTLMNACYP3A4 | |
| SCHEMBL8526183 | 0.73 | ABCC1 (0.54) | ALDH1A1GAAMAPTLMNAALDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885197-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | EP | disclosed |
| US-5807864-A | INCREASING HIGH DENSITY LIPOPROTEIN LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-15 | — | — | US | disclosed |
| WO-1997032855-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-12 | — | — | WO | disclosed |