Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.43 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8609192 | 0.84 | ALDH1A1 (0.50) | HTTALOX15TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL8689693 | 0.82 | HTT (0.44) | HTTSOAT1LMNAALOX15TSHR | |
| SCHEMBL8526183 | 0.81 | ABCC1 (0.54) | ABCC1LMNAKMT2AALDH1A1ALDH2 | |
| SCHEMBL8526420 | 0.78 | ALDH1A1 (0.49) | ABCC1LMNAALOX15CYP2C19KMT2A | |
| SCHEMBL8689690 | 0.75 | NLRP3 (0.42) | HTTSOAT1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL5538230 | 0.74 | HTT (0.50) | HTTSOAT1LMNATDP1KMT2A | |
| SCHEMBL13925886 | 0.73 | SMN1; SMN2 (0.53) | HTTSOAT1LMNATDP1KMT2A | |
| SCHEMBL8526136 | 0.73 | GAA (0.47) | HTTABCC1LMNAALDH1A1ALDH2 | |
| SCHEMBL25197276 | 0.72 | HTT (0.62) | HTTSOAT1LMNATDP1KMT2A | |
| SCHEMBL5533057 | 0.72 | SMN1; SMN2 (0.51) | HTTLMNATDP1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885197-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | EP | disclosed |
| US-5807864-A | INCREASING HIGH DENSITY LIPOPROTEIN LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-15 | — | — | US | disclosed |
| WO-1997032855-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-12 | — | — | WO | disclosed |