Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8526420 | 0.84 | ALDH1A1 (0.49) | CYP1A2ALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL4936197 | 0.78 | MAPT (0.50) | CYP1A2ALDH1A1POLBGAALMNA | |
| SCHEMBL8609192 | 0.77 | ALDH1A1 (0.50) | ALDH1A1POLBSMN1; SMN2ALOX12HPGD | |
| SCHEMBL8526136 | 0.76 | GAA (0.47) | ALDH1A1POLBGAALMNACYP3A4 | |
| SCHEMBL8684648 | 0.76 | POLB (0.46) | CYP1A2ALDH1A1POLBGAALMNA | |
| SCHEMBL4937216 | 0.69 | MEN1 (0.49) | ALDH1A1POLBSMN1; SMN2ALOX12HPGD | |
| SCHEMBL23666238 | 0.69 | LMNA (0.57) | CYP1A2ALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL7171188 | 0.68 | MEN1 (0.51) | CYP1A2ALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL7822207 | 0.68 | HDAC3 (0.65) | CYP1A2ALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL9532514 | 0.68 | ALDH1A1 (0.42) | CYP1A2ALDH1A1POLBGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885197-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | EP | disclosed |
| US-5807864-A | INCREASING HIGH DENSITY LIPOPROTEIN LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-15 | — | — | US | disclosed |
| WO-1997032855-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-12 | — | — | WO | disclosed |