SCHEMBL8526541

SCHEMBL8526541

CON=C(C(=O)N(C)Cc1cc(C2CCc3cc(F)ccc32)ccc1O)c1ccccc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.34
PIN1 Q13526 3/20 0.33
PDK1 Q15118 1/20 0.33
PDK2 Q15119 1/20 0.33
PDK3 Q15120 1/20 0.33
PDK4 Q16654 1/20 0.33
NAMPT P43490 1/20 0.33
SLC6A9 P48067 1/20 0.33
KDM1A O60341 1/20 0.32
MTNR1B P49286 1/20 0.32
CYP17A1 P05093 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP11B1 P15538 1/20 0.32
CYP11B2 P19099 1/20 0.32
HTR6 P50406 2/20 0.31
SLC6A2 P23975 1/20 0.31
SLC6A4 P31645 1/20 0.31
SLC6A3 Q01959 1/20 0.31
TRPM8 Q7Z2W7 1/20 0.30
DRD2 P14416 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8530606 0.90 KIF11 (0.35) KMT2APDK1PDK2PDK3PDK4
SCHEMBL8529282 0.84 KIF11 (0.34)
SCHEMBL8527009 0.79 SLC6A4 (0.35) SLC6A2SLC6A4SLC6A3
SCHEMBL8527421 0.74 KDM4E (0.33) PIN1MTNR1BCYP17A1CYP3A4CYP11B1
SCHEMBL8527784 0.70 PIN1 (0.33) PIN1
SCHEMBL8526539 0.68 HIF1A (0.46) KMT2ASLC6A2SLC6A4SLC6A3
SCHEMBL27795570 0.65 GAA (0.38) KMT2A
SCHEMBL8527040 0.65 HAO1 (0.41) KMT2APIN1SLC6A2SLC6A3
SCHEMBL28843586 0.64 SMN1; SMN2 (0.38) KMT2AHTR2A
SCHEMBL8530444 0.64 HIF1A (0.35) KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5739140-A AGRICULTURAL FUNGICIDES MONSANTO COMPANY (US) 1998-04-14 US disclosed