SCHEMBL8526587

SCHEMBL8526587

C=CCOc1c(C(=O)NC(C)N2CCOCC2)cc(Br)c2ccccc12

nearest known ligand 0.43

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
DRD3 P35462 11/20 0.43
DRD2 P14416 4/20 0.41
SIGMAR1 Q99720 10/20 0.39
DRD4 P21917 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9089128 0.99 DRD3 (0.43) DRD3DRD2SIGMAR1DRD4
SCHEMBL8527025 0.86 DRD3 (0.46) DRD3DRD2SIGMAR1
SCHEMBL8528436 0.85 DRD3 (0.52) DRD3DRD2SIGMAR1
Hydrochloric Acid SCHEMBL9091460 0.85 DRD3 (0.45) DRD3DRD2SIGMAR1
SCHEMBL8526588 0.80 DRD3 (0.61) DRD3DRD2SIGMAR1
Hydrochloric Acid SCHEMBL8527267 0.80 DRD3 (0.61) DRD3DRD2SIGMAR1
SCHEMBL8526537 0.71 SIGMAR1 (0.58) DRD3DRD2SIGMAR1DRD4
SCHEMBL8526354 0.70 DRD2 (0.43) DRD3DRD2
SCHEMBL8527029 0.67 DRD3 (0.67) DRD3DRD2SIGMAR1
SCHEMBL8525948 0.67 DRD3 (0.78) DRD3DRD2SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0539281-B1 Naphthamides, process for their preparation and their application in the therapeutical field INST NAT SANTE RECH MED (FR) 1998-12-30 EP claimed