SCHEMBL8527199

SCHEMBL8527199

CCNP(=O)(OC(=O)c1c(Cl)cccc1[Si](C)(C)C)OC(=O)c1c(Cl)cccc1[Si](C)(C)C

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.36
GAA P10253 1/20 0.36
ABL1 P00519 2/20 0.36
SRC P12931 2/20 0.36
POLB P06746 3/20 0.36
RAB9A P51151 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
LMNA P02545 1/20 0.35
TYK2 P29597 5/20 0.35
JAK2 O60674 4/20 0.35
JAK1 P23458 4/20 0.35
HPGD P15428 1/20 0.34
CYP3A4 P08684 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
MAPT P10636 1/20 0.33
PTK2B Q14289 1/20 0.33
FEN1 P39748 1/20 0.33
NPC1 O15118 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8528983 0.77 JAK2 (0.39) ALDH1A1GAAPOLBRAB9AL3MBTL1
SCHEMBL6429960 0.77 POLB (0.52) ALDH1A1GAAABL1SRCPOLB
SCHEMBL7224446 0.76 HPGD (0.46) ALDH1A1POLBRAB9ATYK2JAK2
SCHEMBL7845245 0.71 POLB (0.46) ALDH1A1POLBRAB9AL3MBTL1HPGD
SCHEMBL6428937 0.71 DOT1L (0.50) ALDH1A1GAAABL1POLBRAB9A
SCHEMBL7856726 0.71 GHSR (0.42) ALDH1A1POLBL3MBTL1HPGDMEN1
SCHEMBL7852285 0.71 TSHR (0.43) ALDH1A1GAAPOLBRAB9AL3MBTL1
SCHEMBL7223500 0.70 FEN1 (0.37) ALDH1A1GAAABL1SRCPOLB
SCHEMBL7846596 0.70 HPGD (0.45) ALDH1A1POLBRAB9ATYK2JAK2
SCHEMBL7853870 0.69 HPGD (0.51) ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5849723-A Fungicides for the control of take-all disease of plants MONSANTO COMPANY (US) 1998-12-15 US disclosed
US-5834447-A THIOPHENE DERIVATIVES MONSANTO COMPANY (US) 1998-11-10 US disclosed
US-5811411-A Fungicides for the control of take-all disease of plants MONSANTO COMPANY (US) 1998-09-22 US disclosed
US-5705513-A HETEROCYCLIC FUNGICIDES WITH PYRIDINE OR FURAN RINGS MONSANTO COMPANY (US) 1998-01-06 US disclosed
US-5693667-A Fungicides for the control of take-all disease of plants MONSANTO COMPANY (US) 1997-12-02 US disclosed