Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.53 |
| ▸ | MME | P08473 | 1/20 | 0.49 |
| ▸ | ECE1 | P42892 | 1/20 | 0.49 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.48 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.47 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSH | P09668 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11888311 | 1.00 | CTSK (0.53) | CTSKMMEECE1CTRB1PSMB1 | |
| SCHEMBL3397821 | 0.89 | CTSK (0.55) | CTSKMMEECE1CTRB1PSMB1 | |
| SCHEMBL116395 | 0.87 | CTSK (0.56) | CTSKCTRB1PSMB1PSMB5PSMB2 | |
| SCHEMBL8458845 | 0.86 | CTRB1 (0.50) | CTSKMMEECE1CTRB1PSMB1 | |
| SCHEMBL7349773 | 0.86 | CTRB1 (0.50) | CTSKMMEECE1CTRB1PSMB1 | |
| SCHEMBL20953619 | 0.86 | CTSK (0.55) | CTSKCTRB1PSMB1PSMB5PSMB2 | |
| SCHEMBL14285574 | 0.86 | CTSK (0.55) | CTSKCTRB1PSMB1PSMB5PSMB2 | |
| SCHEMBL7732224 | 0.85 | CTSK (0.63) | CTSKCTRB1CTSBCTSL | |
| SCHEMBL14527881 | 0.84 | CTSK (0.65) | CTSKCTSBCTSLCTSH | |
| SCHEMBL7417702 | 0.84 | CTSK (0.65) | CTSKCTSBCTSLCTSH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821331-A | INHIBIT THE PROTEOLYTIC ACTIVITY OF PROTEASES | ELI LILLY AND COMPANY (US) | 1998-10-13 | — | — | US | disclosed |
| EP-0386611-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1990-09-12 | — | — | EP | disclosed |