Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 8/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 9/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8529832 | 0.80 | RHEB (0.41) | RHEBP2RX7 | |
| SCHEMBL8527598 | 0.76 | P2RX7 (0.39) | RHEBF7LTA4HF3AHR | |
| SCHEMBL2116708 | 0.75 | RHEB (0.51) | RHEBAHR | |
| SCHEMBL8528724 | 0.73 | P2RX7 (0.40) | RHEBP2RX7 | |
| SCHEMBL8526249 | 0.70 | P2RX7 (0.35) | RHEBP2RX7 | |
| SCHEMBL8529419 | 0.70 | AXL (0.48) | RHEBF7LTA4HF3AHR | |
| SCHEMBL15704604 | 0.69 | TSHR (0.43) | RHEBP2RX7 | |
| SCHEMBL31416308 | 0.69 | RHEB (0.50) | RHEBF7LTA4HF3AHR | |
| SCHEMBL830446 | 0.69 | RHEB (0.50) | RHEBF7LTA4HF3AHR | |
| SCHEMBL827421 | 0.68 | CTRC (0.39) | RHEBP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834494-A | SEROTONIN 5HT2B/2C RECEPTOR ANTAGONISTS; CNS NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS; IRRITABLE BOWEL SYNDROME | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-11-10 | — | — | US | disclosed |
| EP-0707581-B1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-02-26 | — | — | EP | disclosed |
| EP-0707581-A1 | INDOLINE DERIVATIVES AS 5HT 2C? ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995001976-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-01-19 | — | — | WO | disclosed |