Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NR1D1 | P20393 | 9/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.43 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 3/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8527559 | 1.00 | MAPT (0.48) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8423298 | 0.92 | MAPT (0.46) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8423297 | 0.92 | MAPT (0.46) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8528928 | 0.81 | NR1D1 (0.48) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8528925 | 0.81 | NR1D1 (0.48) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8530056 | 0.81 | CTSS (0.45) | MAPTALDH1A1CTSSCTSKKDM4E | |
| SCHEMBL8530060 | 0.81 | CTSS (0.45) | MAPTALDH1A1CTSSCTSKKDM4E | |
| SCHEMBL8422157 | 0.81 | CTSS (0.45) | CTSSCTSKCTSLCTSB | |
| SCHEMBL8422158 | 0.81 | CTSS (0.45) | CTSSCTSKCTSLCTSB | |
| SCHEMBL3784750 | 0.77 | PPARG (0.59) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705257-B1 | AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS | WELLCOME FOUND (GB) | 1998-03-11 | — | — | EP | disclosed |